In the meantime, lymph nodes that are normal in size can be involved with metastases. As a woman ages, much of the gland and duct tissues are replaced with fat. The glands of the breast also start to develop during puberty. An extensive study conducted at the Instituto Nazionale Tumori di Milano reported
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With general recognition that axillary resection is rather a prognostic than a therapeutic procedure, increasing interest in preoperative axillary node staging is evident. Positron emission tomography should permit the recognition of involved lymph nodes due to increased metabolic activity of malignant tissue regardless of size, but in practice it is still inca- pable of detecting micrometastases. These changes include higher estrogen and progesterone levels in the body. For this reason, the breasts are upper quadrant of breast organs of the female reproductive system.